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Postdoctoral Position in Molecular and Genome-Wide Studies of Chromosomal DNA Replication (Dunphy Lab)

A postdoctoral position is open in the laboratory of Dr. William G. Dunphy at the California Institute of Technology (Caltech).  The research involves the mechanisms by which human cells maintain genomic integrity by replicating their DNA faithfully during the cell cycle.  Failures in such mechanisms can lead to cancer and other diseases.  To unravel these mechanisms, we study how cells initiate DNA replication at the right time and place during the cell cycle.  We also investigate what happens when problems occur during replication or the DNA becomes damaged during the process.  We largely focus on proteins called Treslin and TopBP1, which are crucial for both DNA replication and checkpoint responses to replication stress.  For our studies, we use both Xenopus egg extracts and human tissue culture cells as model systems.  For this position, the postdoctoral researcher will focus principally on the mechanisms by which Treslin regulates how, where, and when the initiation of DNA replication occurs throughout the human genome.  Applicants should have experience in cell biology, biochemistry, and molecular biology.  Experience in genomics and bioinformatics would be desirable. 

For additional information, please visit /people/william-g-dunphy. 

For a complete list of publications, see


Please send a curriculum vitae and names of three references to: Dr. William G. Dunphy, Grace C. Steele Professor of Biology, California Institute of Technology (E-mail:


We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, or national origin, disability status, protected veteran status, or any other characteristic protected by law.